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Parkinson's Disease, 1st Edition  
รหัส : 9780123740281
ยี่ห้อ : Elsevier
รุ่น : Richard Nass, Serge Przedborski
ราคาปกติ :  5,195.00      
ราคาพิเศษ :  4,895.00
รายละเอียดย่อ :
Parkinson's Disease : Molecular and Therapeutic Insights From Model Systems
Author:Richard Nass,Serge Przedborski Richard Nass,Serge Przedborski
ISBN : 9780123740281
Edition : 1/2008
Imprint : Elsevier
Page Count : 686 p.
รายละเอียดทั้งหมด :

Description :

Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery.

Key Features :

  • Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson’s disease
  • Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD
  • Current overviews of current status of PD research and discovery from bench-to-bedside
  • Provides novel insights and views on where the future of PD research may lead
  • Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases

Contents :

List of Contributors



Part I: Clinical Overview

o    Chapter 1 - Clinical Aspects of Parkinson Disease

o    Chapter 2 - Genetics of Parkinson's Disease

o    Chapter 3 - Neuropathology of Parkinson's Disease1

Part II: Non-Human Primate Models

o    Chapter 4 - Introduction to: Neurotoxin-based Nonhuman Primate Models of Parkinson's Disease

o    Chapter 5 - Systems Level Physiology of the Basal Ganglia, and Pathophysiology of Parkinson's Disease

o    Chapter 6 - Neuroprotection for Parkinson's Disease: Clinically Driven Experimental Design in Non-human Primates

o    Chapter 7 - The use of aged monkeys to study pd: important roles in pathogenesis and experimental therapeutics

o    Chapter 8 - 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Mammalian Models of Parkinson's Disease: Potential Uses and Misuses of Acute, Sub-acute, and Chronic Models

o    Chapter 9 - Non-human Primate Models of Parkinson's Disease and Experimental Therapeutics

Part III: Rodent Toxin Models

o    Chapter 10 - Rodent Toxin Models of PD: An Overview

o    Chapter 11 - The MPTP Mouse Model of Parkinson's Disease: the True, the False, and the Unknown

o    Chapter 12 - Acute and chronic administration of 1-methyl-4-phenylpyridinium

o    Chapter 13 - Endogenous Defenses that Protect Dopamine Neurons: Studies with 6-ohda Models of Parkinson's Disease

o    Chapter 14 - Complex I Inhibition, Rotenone and Parkinson's Disease

o    Chapter 15 - Paraquat-induced Neurodegeneration: a Model of Parkinson's Disease Risk Factors

Part IV: Rodent And Other Vertebrate Genetic Models

o    Chapter 17 - Genetic Models of Familial Parkinson's Disease

o    Chapter 18 - The Dynamics of α-Synuclein at the Nerve Terminal

o    Chapter 19 - The Bac Transgenic Approach to Study Parkinson's Disease in Mice

o    Chapter 20 - Viral Vectors: A Potent Approach to Generate Genetic Models of Parkinson's Disease

o    Chapter 21 - Environmental Explorations of Parkinson's Disease Using Rodent Genetic Models

o    Chapter 22 - α-Synuclein, CSPα, SNAREs and Neuroprotection in vivo

o    Chapter 23 - Insights from Zebrafish PD Models and Their Potentials for Identifying Novel Drug Targets and Therapeutic Compounds

Part V: Multicellular Invertebrate Models

o    Chapter 24 - Parkinson's Disease: Insights from Invertebrates

o    Chapter 25 - Drosophila Models for Parkinson's Disease Research

o    Chapter 26 - Caenorhabditis Elegans Models of Parkinson's Disease: A Robust Genetic System to Identify and Characterize Endogenous and Environmental Components Involved in Dopamine Neuron Degeneration

o    Chapter 27 - C. Elegans Genetic Strategies to Identify Novel Parkinson's Disease-associated Therapeutic Targets and Leads

o    Chapter 28 - Overview: cell-based models of parkinson's disease

o    Chapter 29 - PC12 Cells as a model for parkinson's disease research

o    Chapter 30 - Dissociated mesencephalic cultures: A research tool to model dopaminergic cell death in parkinson's disease

o    Chapter 31 - Selective Autophagy in the Pathogenesis of Parkinson's Disease

o    Chapter 32 - The Role of LRRK2 Kinase Activity in Cellular PD Models

o    Chapter 33 - Using yeast as a model system for the genetic dissection of α-synuclein toxicity

o    Chapter 34 - The role of the foxa2 gene in the birth and death of dopamine neurons

o    Chapter 35 - Embryonic stem cell-based models of parkinson's disease

o    Chapter 36 - Neuroprotective and Neurotoxic Properties of α-Synuclein in Cell Culture Models of Dopaminergic Degeneration

o    Chapter 37 - Postnatally Derived Ventral Midbrain Dopamine Neuron Cultures as a Model System for Studying Neurotoxicity and Parkinson's Disease

o    Chapter 38 - Yeast Cells as a Discovery Platform for Parkinson's Disease and other Protein Misfolding Diseases

Part VII: Cell-Free Models

o    Chapter 39 - Overview of cell-free systems for the study of parkinson's disease

o    Chapter 40 - Microglial activation in a mouse model of α-synuclein overexpression

o    Chapter 41 - Purification and Quantification of Neural α-synuclein: Relevance for Pathogenesis and Biomarker Development

o    Chapter 42 - Protein Folding and Aggregation in in vitro Models of Parkinson's Disease: Structure and Function of α-Synuclein

o    Chapter 43 - The use of cell-free systems to characterize parkinson's disease-related gene products




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