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Adenoviral Vectors for Gene Therapy 1st Edition  
รหัส : 9780121995041
ยี่ห้อ : David T. Curiel , Joanne T. Douglas
รุ่น : Elsevier
ราคาปกติ :  9,225.00      
ราคาพิเศษ :  8,925.00
รายละเอียดย่อ :
Adenoviral Vectors for Gene Therapy 1st Edition
Editors: David T. Curiel , Joanne T. Douglas
Hardcover ISBN: 9780121995041
Imprint: Academic Press
Copyright © 2002 Elsevier Inc. All rights reserved
Page Count: 890
รายละเอียดทั้งหมด :

 Description :

          Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.

Table of Contents :

  • Chapter 1 - Adenovirus Structure
  • Chapter 2 - Biology of Adenovirus Cell Entry
  • Chapter 3 - Adenovirus Replication
  • Chapter 4 - Adenoviral Vector Construction I: Mammalian Systems
  • Chapter 5 - Adenoviral Vector Construction II: Bacterial Systems
  • Chapter 6 - Propagation of Adenoviral Vectors: Use of PER. C6 Cells
  • Chapter 7 - Purification of Adenovirus
  • Chapter 8 - Targeted Adenoviral Vectors I: Transductional Targeting
  • Chapter 9 - Targeted Adenoviral Vectors II: Transcriptional Targeting
  • Chapter 10 - Development of Attenuated Replication Competent Adenoviruses (ARCAs) for
  • the Treatment of Prostate Cancer
  • Chapter 11 - Replication-Selective Oncolytic Adenovirus E1-Region Mutants: Virotherapy for
  • Cancer
  • Chapter 12 - Innate Immune Responses to in Vivo Adenovirus Infection
  • Chapter 13 - Humoral Immune Response
  • Chapter 14 - Novel Methods to Eliminate the Immune Response to Adenovirus Gene   
  • Therapy
  • Chapter 15 - High-Capacity “Gutless” Adenoviral Vectors: Technical Aspects and
  • Applications
  • Chapter 16 - Xenogenic Adenoviral Vectors
  • Chapter 17 - Hybrid Adenoviral Vectors
  • Chapter 18 - Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer
  • Chapter 19 - Utility of Adenoviral Vectors in Animal Models of Human Disease II: Genetic
  • Disease
  • Chapter 20 - Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired
  • Diseases
  • Chapter 21 - Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations
  • Chapter 22 - Imaging Adenovirus-Mediated Gene Transfer
  • Color Plates


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