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Chemistry and Biology of Heparin and Heparan Sulfate 1st Edition  
รหัส : 9780080448596
ยี่ห้อ : Elsevier Science
รุ่น : Hari Garg, Robert Linhardt, Charles Hales
ราคาปกติ :  15,600.00      
ราคาพิเศษ :  12,600.00
รายละเอียดย่อ :
Chemistry and Biology of Heparin and Heparan Sulfate 1st Edition
ISBN: 978008044859
Author: Hari Garg, Robert Linhardt, Charles Hales
Copyright : 1ed©2005
Hardcover »792 pages.
รายละเอียดทั้งหมด :

Descriptions :

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area.

Table of contents :

Preface,   Contributors

  • Chapter 1 - Structure and Active Domains of Heparin
  • Chapter 2 - Structure and Function of Cell Associated and Pericellular Heparan Sulfate Proteoglycans,
  • Chapter 3 - Methods for Structural Analysis of Heparin and Heparan Sulfate
  • Chapter 4 - Synthetic Approach to Define Structure-Activity Relationship of Heparin and Heparan Sulfate
  • Chapter 5 - Biochemical and Pharmacologic Rationale for Synthetic Heparin Polysaccharides
  • Chapter 6 - Separation and Sequencing of Heparin and Heparan Sulphate Saccharides
  • Chapter 7 - Biosynthesis of Heparin and Heparan Sulfate
  • Chapter 8 - Remodeling of Heparan Sulfate Sulfation by Extracellular Endosulfatases
  • Chapter 9 - Heparan Sulfate Degradation by Heparanases.
  • Chapter 10 - Lysosomal Degradation of Heparin and Heparan Sulfate.
  • Chapter 11 - Heparin Regulation of the Complement System.
  • Chapter 12 - Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins,
  • Chapter 13 - Heparin Activation of Serpins.
  • Chapter 14 - Role of Heparan Sulfate in Fibroblast Growth Factor Signaling.
  • Chapter 15 - Role of Anticoagulant Heparan Sulfate in Mammalian Reproduction
  • Chapter 16 - Glycol-Splitting as a Device for Modulating Inhibition of Growth Factors and Heparanase by Heparin and Heparin Derivatives.
  • Chapter 17 - Antithrombin Activation and Designing Novel Heparin Mimics.
  • Chapter 18 - Influence of Heparin Chemical Modifications on its Antiproliferative Properties.
  • Chapter 19 - Mechanisms of Cell Growth Regulation by Heparin and Heparan Sulfate.
  • Chapter 20 - Heparin and Low Molecular Weight Heparin in Thrombosis and Inflammation: Emerging Links.
  • Chapter 21 - Basic and Clinical Differences of Heparin and Low Molecular Weight Heparin Treatment.
  • Chapter 22 - Perlecan: An Extracellular Matrix Heparan Sulfate Proteoglycan that Regulates Key Events in Vascular Development and Disease.
  • Chapter 23 - Heparin and Low Molecular Weight Heparins in Clinical Cardiology.
  • Chapter 24 - Heparin-Induced Thrombocytopenia.
  • Chapter 25 - Role of Heparan Sulfate in Cancer,.
  • Chapter 26 - Use of Heparin Preparations in Older Patients,.
  • Chapter 27 - Advances in Low Molecular Weight Heparin Use in Pregnancy. 

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